Science Advances

Supplementary Materials

This PDF file includes:

  • fig. S1. Release of NT-3 from a PLGA np/hydrogel DDS containing encapsulated NT-3 and soluble NT-3.
  • fig. S2. Bioactivity of proteins released from hydrogels with embedded PLGA np.
  • fig. S3. Characteristics of PLGA np used in this study.
  • fig. S4. Swelling of HAMC hydrogel with and without PLGA np.
  • fig. S5. Release of soluble SDF from XMC alone into aCSF at pH 3, pH 5, or pH 7.
  • fig. S6. Mass loss of PLGA from the release system at pH 3 and pH 7.
  • Legend for movies S1
  • Calculation of the relative surface area for PLGA np of different sizes
  • Calculation for maximum surface coverage

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Other Supplementary Material for this manuscript includes the following:

  • movie S1 (.avi format). Two-dimensional Monte Carlo simulations of protein release from a hydrogel with embedded cubic degrading nanoparticles.

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