Science Advances

Supplementary Materials

This PDF file includes:

  • Supplementary Results
  • Supplementary Materials and Methods
  • table S1. QC of data set DE1.
  • table S2. QC of data set DE2.
  • table S3. Genomic inflation.
  • Legends for tables S4 and S5
  • table S6. Replicated mQTLs of rs4925166 and CpG sites in SHMT1.
  • table S7. Mediation analysis.
  • table S8. Causal mediation analysis.
  • fig. S1. Substructure analysis results in DE1.
  • fig. S2. Substructure analysis results in DE2.
  • fig. S3. GWAS with age at onset.
  • fig. S4. Forest plots of all non-MHC top genome-wide significant variants.
  • fig. S5. Locus-specific Manhattan plots.
  • fig. S6. Forest plots of novel variants replicated in a Sardinian cohort.
  • fig. S7. eQTL and mQTL analysis for rs4925166.
  • fig. S8. Transcription factor binding sites.
  • References (70–75)

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Other Supplementary Material for this manuscript includes the following:

  • table S4 (Microsoft Excel format). Genome-wide significant loci.
  • table S5 (Microsoft Excel format). eQTLs with FDR <0.05 in data set DE1.

Download Tables S4 and S5

Files in this Data Supplement: