Science Advances

Supplementary Materials

This PDF file includes:

  • fig. S1. Dosing and toxicity assessment of hybrid and bacterial vectors.
  • fig. S2. Histological intranasal toxicity evaluation of hybrid devices.
  • fig. S3. The pLF consolidation design and organization.
  • ig. S4. Challenge levels of D39.
  • fig. S5. Bacterial burden assessed for hybrid vector vaccination with the consolidated antigens against pneumococcal challenge strains that included D39, A66.1, WU2, and TIGR4 in either a sepsis or pneumonia model.
  • fig. S6. Probability of mutations occurring in S. pneumoniae genes (glpO, pncO, dexB, and stkP) through cellular division.
  • fig. S7. Synthetic scheme for PBAE D4A4-Man.
  • table S1. DexB, GlpO, StkP, and PncO antigen description and analysis.
  • table S2. Antigen cloning summary.
  • table S3. Consolidated plasmid (pLF) cloning summary.
  • table S4. S. pneumoniae strains used in the current study.
  • Reference (23)

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