Science Advances

Supplementary Materials

This PDF file includes:

  • fig. S1. Targeting strategy for disrupting the Polrmt gene in mouse.
  • fig. S2. ECG analysis of conditional Polrmt knockout mice.
  • fig. S3. Total protein levels of nuclear-encoded factors involved in mtDNA expression.
  • fig. S4. Steady-state mitochondrial protein levels of conditional Polrmt knockout mice.
  • fig. S5. Relative mitochondrial protein distribution across a gradient.
  • fig. S6. Relative mitochondrial protein distribution in Polrmt knockout mice.
  • fig. S7. Respiratory chain complex protein levels in heterozygous Polrmt knockout mice.
  • fig. S8. Relative mitochondrial RNA abundance in heterozygous Polrmt knockout mice.
  • fig. S9. Steady-state mitochondrial protein levels in heterozygous Polrmt knockout hearts.
  • fig. S10. mtDNA levels in heterozygous Polrmt knockout hearts.
  • table S1. Summary statistics and P values of RT-qPCR presented in Fig. 4B.

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