Science Advances

Supplementary Materials

This PDF file includes:

  • Legends for tables S1 to S8
  • fig. S1. Schematic illustration of the calculation process of the Δ scores.
  • fig. S2. Analysis of the average correlation between mRNA and protein levels.
  • fig. S3. Analysis of ΔBI–III scores of random sets of genes.
  • fig. S4. ΔSNPC scores corresponding to aggregation-prone protein sets characteristic of PD.
  • fig. S5. Distributions of Δ scores for tissues affected at different Braak stages.
  • fig. S6. Proteome-based Δ scores calculated using mice data for tissues affected at different Braak stages.
  • fig. S7. ΔBI–III Scores for neurodegenerative disease–specific aggregation modulator sets.

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Other Supplementary Material for this manuscript includes the following:

  • table S1 (Microsoft Excel format). Mapping between Braak regions and Allen Brain Atlas regions.
  • table S2 (Microsoft Excel format). Δ Scores for the reference proteome.
  • table S3 (Microsoft Excel format). Proteins that aggregate in neurodegenerative disease.
  • table S4 (Microsoft Excel format). Modulators of Aβ and tau aggregation.
  • table S5 (Microsoft Excel format). Brain regions colored in Fig. 3A.
  • table S6 (Microsoft Excel format). Aggregation modulator Δ scores for all Braak stages.
  • table S7 (Microsoft Excel format). KEGG pathways.
  • table S8 (Microsoft Excel format). Data sources.

Download tables S1 to S8

Files in this Data Supplement: