Science Advances

Supplementary Materials

This PDF file includes:

  • fig. S1. Structure-based sequence alignment of the catalytic core domains of human, mouse, gecko, and zebrafish PrimPols.
  • fig. S2. Overall structures of PrimPol and yPol╬Ě ternary complexes with template-primer DNA and dNTP.
  • fig. S3. Simulated annealing Fo-Fc omit map for dATP, templating base T3, and Ca2+ residues within the PrimPol active-site region.
  • fig. S4. Overall structures of human PrimPol-DNA-dNTP complex and human primase PriS complex with uridine triphosphate.
  • table S1. Crystallographic parameters and refinement statistics.

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