Science Advances

Supplementary Materials

This PDF file includes:

  • fig. S1. Optimization of metformin concentration for codrug screen.
  • fig. S2. Effect of metformin on cell survival in leukemic blasts.
  • fig. S3. Syrosingopine-metformin titration in leukemic blasts.
  • fig. S4. Effect of drug combination on 2D and 3D culture conditions.
  • fig. S5. Effect of syrosingopine with phenformin and other mitochondrial inhibitors.
  • fig. S6. Syrosingopine strongly potentiates the effect of mitochondrial inhibitors.
  • fig. S7. Syrosingopine-metformin titrations of Eno2-expressing and Eno2-nonexpressing cells.
  • fig. S8. Eno2 knockout does not confer sensitivity to drug combination.
  • table S1. Panel of cancer cell lines tested for syrosingopine-metformin–induced synthetic lethality.

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