Science Advances

Supplementary Materials

This PDF file includes:

  • table S1. Multicontrast nonlinear imaging to observe various tumor microenvironment events.
  • table S2. New knowledge acquisition by dimension-increased multicontrast image analysis of a rat mammary tumor.
  • table S3. Observed micrometer-sized vesicles in mammary tissue classified by cross-contrast visibility and chemical content.
  • table S4. Macroscopic events observed in tumor microenvironments and in nontumor mammary samples.
  • fig. S1. Schematic for label-free multicontrast nonlinear imaging.
  • fig. S2. Coregistered multicontrast images of an unperturbed mammary tumor from a carcinogen-injected rat.
  • fig. S3. Coregistered single-contrast images of an unperturbed normal human mammary specimen.

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Other Supplementary Material for this manuscript includes the following:

  • movie S1 (.mp4 format). Sweeping of hyperspectral χ(3)CRS images from the middle-right corner of Fig. 1C.
  • movie S2 (.mp4 format). Comparison of coregistered multicontrast images from the adipocyte-dominant control mammary tissue sample (Fig. 2, main) and the precancerous mammary sample (Fig. 4, main).

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