Science Advances

This PDF file includes:

• Supplementary Materials and Methods
  
• fig. S1. Data matrix containing 72 taxa (rows) and 151 characters (columns).
  
• fig. S2. Complements regarding the coding procedure.
  
• fig. S3. Phylogenetic relationships among the sequences that were used to reconstruct AncSR_AC and AncSR_D.
  
• fig. S4. Temporal relationships among steroid synthesis pathways, inferred from a 50% majority-rule consensus parsimony tree.
  
• fig. S5. Detailed view of animal steroid metabolic pathways.
  
• Legends for tables S1 and S2
  
• References (82–86)

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Other Supplementary Material for this manuscript includes the following:

• table S1 (Microsoft Excel format). Accession numbers for the 142 sequences used for the predictions of the ancestral receptors.
  
• table S2 (Microsoft Excel format). Sequences of the LBDs for the two reconstructed receptors.

Download Tables S1 and S2