Science Advances

Supplementary Materials

This PDF file includes:

  • fig. S1. MDST histology.
  • fig. S2. Sensitivity of MDST lines to genotoxic treatment.
  • fig. S3. Intrinsic clustering analysis of MDST models and GEMMs.
  • fig. S4. MDST sensitivity to tamoxifen.
  • fig. S5. Predictive power of MDST models for tumor sensitivity to targeted inhibition.
  • fig. S6. In vitro induction of DNA damage in MDST cells.
  • fig. S7. Correlation between PARP1 protein expression and PARP inhibitor sensitivity in cell lines.
  • fig. S8. Development and initial validation of the PSP score.
  • table S1. Relative expression levels of EMT genes by RNA-seq.
  • table S2. Amplification, mutation, and deletion frequencies of genes commonly altered in human breast invasive carcinomas and differentially expressed in multiple MDST models.
  • table S3. Somatic mutations in MDST models.
  • table S4. PSP signature gene list.
  • table S5. Statistical analysis of growth rate differences between MDST models.
  • section S1. Histopathology report.

Download PDF

Files in this Data Supplement: