Science Advances

Supplementary Materials

This PDF file includes:

  • Reliability of time scales
  • Master equation
  • Effect of force field
  • fig. S1. Empirical (dashed line) and fitted cumulative distribution functions (solid line).
  • fig. S2. Residence time, eigenvector, and eigenvalue analysis.
  • fig. S3. FES as a function of ligand-binding pocket distance d (in nanometers) and hydration state of binding pocket w calculated using the second set of force fields.
  • table S1. Residence times and P values for various states
  • table S2. Matrix K of state-to-state transition rates.

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