Science Advances

Supplementary Materials

This PDF file includes:

  • fig. S1. Comparisons between cognitive assessment evaluations and the KF-based predictions of AD progression.
  • fig. S2. Synthesized Aβ was used to show the influence of a freeze-thaw cycle on the peptide and protein particle aggregation.
  • fig. S3. Identifying Aβ-embedded protein aggregates within the CSF.
  • fig. S4. Nanomorphology of tau-embedded proteins within the CSF during AD pathogenesis.
  • fig. S5. Age- and gender-related analysis.
  • fig. S6. Particle size, shown as the size of white spots.
  • fig. S7. Dynamics of nanocharacterization and cognitive assessment data in AD progression.
  • fig. S8. AD stages of a female patient determined by cognitive assessments and KF-based diagnosis.
  • fig. S9. Data analysis of nanomorphology using image processing.
  • table S1. Human subjects for CSF samples.
  • table S2. Human subjects for serum samples.
  • table S3. Details of experimental data sets of CSF-based characterization.
  • table S4. Details of experimental data sets of serum-based characterization.
  • table S5. MMSE and SAGE scores.

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