Science Advances

Supplementary Materials

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  • fig. S1. Number of encapsulated enzyme and polymersome size distribution.
  • fig. S2. Schematic representation of the observation NanoSight chamber.
  • fig. S3. Asymmetric polymersomes loaded with catalase in the presence of
    homogeneously dissolved hydrogen peroxide.
  • fig. S4. Asymmetric polymersomes loaded with glucose oxidase in the presence
    of homogeneously dissolved glucose.
  • fig. S5. Asymmetric polymersomes loaded with catalase and glucose oxidase in
    the presence of homogeneously dissolved glucose.
  • fig. S6. Symmetric polymersomes loaded with catalase and glucose oxidase after
    the injection of PBS (that is, no gradient).
  • fig. S7. Asymmetric empty polymersomes after the injection of PBS (that is, no
    gradient).
  • fig. S8. Asymmetric polymersomes loaded with catalase and glucose oxidase after
    the injection of PBS (that is, no gradient).
  • fig. S9. Symmetric PMPC-PDPA polymersomes loaded with catalase and glucose
    oxidase in the presence of a glucose gradient.
  • fig. S10. Symmetric PEO-PBO polymersomes loaded with catalase and glucose
    oxidase in the presence of a glucose gradient.
  • fig. S11. Asymmetric empty polymersomes in the presence of a glucose gradient.
  • fig. S12. Asymmetric empty polymersomes in the presence of a hydrogen
    peroxide gradient.
  • fig. S13. Asymmetric polymersomes loaded with catalase in the presence of a
    hydrogen peroxide gradient.
  • fig. S14. Asymmetric polymersomes loaded with glucose oxidase in the presence
    of a glucose gradient.
  • fig. S15. Asymmetric polymersomes loaded with catalase and glucose oxidase in
    the presence of a glucose gradient.
  • fig. S16. Asymmetric PEO-PBO polymersomes loaded with catalase and glucose
    oxidase in the presence of a glucose gradient.
  • fig. S17. Polymersome concentration in long-range chemotaxis.
  • fig. S18. BBB in vitro model for polymersome qualification.
  • fig. S19. Live cell imaging of LA polymersome real-time transcytosis.
  • table S1. Diffusion simulation parameters.
  • note S1. An agent-based model of nanoparticle propulsion in a capillary.
  • note S2. Long-range chemotaxis.
  • note S3. Simulation model and propulsion velocity fitting.
  • note S4. Diffusion simulations.

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