Science Advances

Supplementary Materials

This PDF file includes:

  • fig. S1. BmP01 activates TRPV1 by increasing the open probability.
  • fig. S2. BmP01 inhibits Kv1.3 channel.
  • fig. S3. Effects of BmP01 on TRPV1, TRPV3, and their chimeras.
  • fig. S4. Effects of BmP01 on TRPV1 outer pore mutants.
  • fig. S5. Low pH potentiates TRPV1 current response to toxins in the α-KTX8 toxin subfamily.
  • fig. S6. Concentration-response curves used for the determination of coupling energy between BmP01 and TRPV1.
  • table S1. Changes in charged fraction of the side chain of titratable residues in BmP01.
  • table S2. BmP01 concentration-response parameters for TRPV1 WT and mutants.
  • table S3. Proton concentration-response parameters for TRPV1 WT and mutants.
  • table S4. BmP01 concentration-response parameters for Kv1.3 under different pH values.

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