Science Advances

This PDF file includes:

• fig. S1. Preparation and crystallization of tLM511E8.
  
• fig. S2. Comparison of the crystal structures of tLM511E8 and mini-E8 of LM111.
  
• fig. S3. Electron microscopic imaging of the LM511E8–α6β1 integrin complex.
  
• fig. S4. Cys-substituted residues on βI domain.
  
• fig. S5. Integrin binding activity of wild-type and Cys-substituted LM511E8s.
  
• fig. S6. Disulfide formation between Cys-substituted LM511E8 and α6β1 integrin.
  
• fig. S7. Disulfide cross-link assays using LM511E8/I1606C/EQ and LM511E8/K1608C/EQ.
  
• fig. S8. Inhibition of the LM511E8–α6β1 integrin interaction by wild-type andΔγ1C5 LM511E8.
  
• table S1. Data collection and refinement statistics.

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