Science Advances

Supplementary Materials

This PDF file includes:

  • fig. S1. Biochemical characterization of wild-type BRCA1-BARD1.
  • fig. S2. Biochemical characterization of mutated BRCA15382insC-BARD1.
  • fig. S3. Changes in the properties of the BRCA15382insC-BARD1 under oxidative conditions.
  • fig. S4. The BRCA15382insC-BARD1 structure is restored following USP2 treatment.
  • Legends for movies S1 to S4
  • table S1. Flow chart of image processing procedures including steps for assessing particle heterogeneity during 2D averaging and 3D classification procedures.

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Other Supplementary Material for this manuscript includes the following:

  • movie S1 (.mov format). Movie of the wild-type BRCA1-BARD1 structure.
  • movie S2 (.mov format). Movie of the mutated BRCA15382insC-BARD1 structure.
  • movie S3 (.mov format). Movie of mutated BRCA15382insC-BARD1 isolated from H2O2-treated cells.
  • movie S4 (.mov format). Movie of mutated BRCA15382insC-BARD1 treated with USP2.

Files in this Data Supplement: