Science Advances

Supplementary Materials

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  • fig. S1. Data analysis pipeline to calculate FIC2 scores from dose-response growth data.
  • fig. S2. Scatterplot of replicate interaction scores (FIC2) for all pairwise drug combinations shown in Fig. 1 (C and D).
  • fig. S3. Correlation among FIC2 scores calculated at different levels of growth inhibition (IC30, IC40, IC50, IC60, and IC70) from the pairwise interaction data set described in Fig. 1 (C and D).
  • fig. S4. Scatterplot of replicate interaction scores (FICn) obtained for all two-way (FIC2), three-way (FIC3), four-way (FIC4), and five-way (FIC5) drug combinations in two replicates for the experiment shown in Fig. 2B.
  • fig. S5. Dose responses of isoniazid in combination with itself in one-way, two-way, three-way, four-way, and five-way combinations.
  • fig. S6. 3D isobole of the checkerboard assay for the isoniazid + clofazimine + bedaquiline interaction.
  • fig. S7. DiaMOND factorization model schematic.
  • fig. S8. Scatterplot of the calculated lower-order (λFICn−1) interaction scores and the geometric mean of FICn−1 scores ( FICn−1 ) from the high-order measurements described in Figs. 2 and 3.
  • method S1. Derivation and formulas to calculate expectation doses.
  • method S2. DiaMOND equation for four-drug combination derived from Eq. 5, approximation, and recursion.

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