Science Advances

Supplementary Materials

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  • Supplementary Methods
  • fig. S1. Wu32 affects the closure step.
  • fig. S2. The charge of the resin acid is required for G(V) shifting effects.
  • fig. S3. Wu32 affects closure but not opening.
  • fig. S4. Small effects of DHA and DHAA on kinetics.
  • fig. S5. Molecular dynamics identifies an interaction site between S3, S4, and the lipid bilayer.
  • fig. S6. Stability of VSD-Wu122 complexes.
  • fig. S7. The negatively charged cluster EEED333-336 is not important for compound-induced G(V) shifts.
  • fig. S8. Wu170 affects closing but not opening.
  • fig. S9. Correlation analysis for 3R Shaker KV channel.
  • fig. S10. The method to calculate conductance (or permeability) does not affect the estimated G(V) shift.
  • table S1. Properties of synthesized compounds.
  • References (47–51)

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