Science Advances

Supplementary Materials

This PDF file includes:

  • Supplementary Materials and Methods
  • table S1. Alcohol and cocaine and cocaethylene levels.
  • fig. S1. Prior alcohol use does not enhance daily cocaine intake.
  • fig. S2. Prior cocaine use decreases preference for alcohol.
  • fig. S3. Initiation of cocaine self-administration on day 11 resulted in decreased alcohol intake in alcohol-primed animals.
  • fig. S4. Acetylation at H3 lysine 27 is a key regulatory mark for FosB.
  • fig. S5. Alcohol use promotes decreased nuclear accumulation of HDAC4 in nucleus accumbens.
  • fig. S6. Chronic alcohol use promotes proteasome-mediated degradation of HDAC5 in the nucleus accumbens.
  • fig. S7. MC1568 treatment does not enhance daily cocaine intake.
  • fig. S8. Subcellular fractionation.

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