Science Advances

Supplementary Materials

This PDF file includes:

  • fig. S1. Metabolomic analysis of melanoma tumors of different sizes.
  • fig. S2. Metabolism of BRAF WT and BRAF Mut tumors.
  • fig. S3. Quantitation of histone H3 trimethylation marks shown in Fig. 2H.
  • fig. S4. Histone marks in primary tumors and their corresponding metastases.
  • fig. S5. Histone methyltransferase expression in H-met and L-met tumors and correlation with H3K9me3 and H3K27me3 abundance.
  • fig. S6. Invasion of H-met and L-met cells in transwell invasion assay.
  • fig. S7. Effect of EZH2 inhibition on H-met cell invasiveness.
  • fig. S8. Assessment of metastasis in visceral organs of mice bearing M481 H-met tumors.
  • fig. S9. Examination of SETDB1 knockdown in UT10 tumor line in vivo.
  • fig. S10. Examination of cystathionine and GSH in M481 primary tumors after SETDB1 or EZH2 knockdown.
  • table S1. Metabolites that discriminate between BRAF WT and BRAF Mut tumors.
  • Legend for table S2
  • table S3. Metabolites related with methylation that are significantly altered in H-met tumors.

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Other Supplementary Material for this manuscript includes the following:

  • table S2 (Microsoft Excel format). Complete isotopolog analysis of all metabolites in PDX-bearing mice infused with U-13Cglucose.

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