Science Advances

Supplementary Materials

This PDF file includes:

  • section S1. Derivation of T2S model
  • section S2. Computational tractability
  • section S3. Model calibration
  • section S4. Gradient direction for iterative optimization
  • section S5. MURA: A separable pattern
  • section S6. FlatCam model: An approximation to the T2S model
  • section S7. Diffraction effects and T2S model
  • section S8. Light collection
  • section S9. Impact of sensor saturation
  • fig. S1. Calibration setup.
  • fig. S2. Digital focusing.
  • fig. S3. Simulation comparison of bare sensor, FlatScope, and FlatCam.
  • fig. S4. 3D volume reconstruction accuracy.
  • fig. S5. Fabrication of FlatScope.
  • fig. S6. Refractive index matching.
  • fig. S7. T2S derivation.
  • fig. S8. Aberration removal using RPCA.
  • fig. S9. Removing effects from autofluorescence.
  • fig. S10. T2S model error from diffraction.
  • fig. S11. Light collection comparison of FlatScope and microscope objectives.
  • Legends for movies S1 and S2

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Other Supplementary Material for this manuscript includes the following:

  • movie S1 (.mp4 format). Digital focusing of simulated resolution target.
  • movie S2 (.mp4 format). Fluorescent beads flowing in microfluidic channels of different depths.

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