Science Advances

Supplementary Materials

This PDF file includes:

  • fig. S1. Phylogenetic analyses of the molecular components of retinoid metabolism and signaling in P. dumerilii.
  • fig. S2. Alignment of RAR sequences.
  • fig. S3. Transactivation assays using the PduRXR.
  • fig. S4. Structural analysis of the LBD of the PduRAR.
  • fig. S5. Expression of RA metabolic enzymes (aldh1a and cyp26) in P. dumerilii.
  • fig. S6. Validation of MOs for microinjection into P. dumerilii zygotes.
  • fig. S7. Effects of ATRA and 13cRA treatments on P. dumerilii larval development.
  • table S1. Data collection and refinement statistics for the PduRAR LBD–ATRA crystal structure complex.
  • Legends for movies S1 and S2
  • References (61, 62)

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Other Supplementary Material for this manuscript includes the following:

  • movie S1 (.avi format). Locomotion of P. dumerilii larvae upon application of exogenous RA.
  • movie S2 (.avi format). Locomotion of P. dumerilii prelarvae upon application of exogenous RA.

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