Science Advances

Supplementary Materials

This PDF file includes:

  • Supplementary data
  • table S1. Mutagenic activity of 6-HAP.
  • table S2. Systemic toxicity of repeated intravascular administration with 6-HAP in mice.
  • fig. S1. Purification of a unique antimicrobial compound from the culture supernatant of S. epidermidis strain MO34 isolated from normal human skin.
  • fig. S2. Molecular mass of purified antibiotic from the S. epidermidis MO34 strain analyzed by HR-ESI-MS.
  • fig. S3. Comparison of chemical shifts of purified antibiotic with those of synthetic 6-HAP in 1H-NMR.
  • fig. S4. The gHMBC spectrum (500 MHz) of 6-HAP in AcOD-D2O.
  • fig. S5. Comparison of the fragmentation profile of purified antibiotic with that of synthetic 6-HAP on electron impact mass spectrometry.
  • fig. S6. Capacity of 6-HAP to directly disrupt plasma membrane of human keratinocytes and sebocytes.
  • fig. S7. Effect of epicutaneous application of S. epidermidis strain producing 6-HAP on the cutaneous immune system in mice.

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Other Supplementary Material for this manuscript includes the following:

  • table S3 (Microsoft Excel format). List of unique marker genes that are present in S. epidermidis strains producing 6-HAP.

Files in this Data Supplement: