Science Advances

Supplementary Materials

This PDF file includes:

  • fig. S1. Domain architecture of ApiPLPs.
  • fig. S2. Structure of TgPLP1 MACPF domain in its helical assembly.
  • fig. S3. Analysis of the predicted conductance properties of TgPLP1 oligomers using the program HOLE.
  • fig. S4. Analysis of the structural stability of TgPLP1 MACPF crystal structures during MD simulation.
  • fig. S5. Comparison of TgPLP1 MACPF oligomeric crystal structures with atomistic simulations showing changes in intersubunit hydrogen bonding.
  • fig. S6. Normalized bar charts showing main intersubunit hydrogen bonds during TgPLP1 MACPF helix and ring simulations.
  • fig. S7. Simulation and hydrogen bond analysis of representative ring and helix interfaces isolated from oligomers to remove oligomeric constraints.
  • fig. S8. Details of TgPLP1 APCβ domain crystal structure.
  • fig. S9. Details of coarse-grained and atomistic TgPLP1 APCβ-membrane simulations.
  • fig. S10. AUC and SAXS study of TgPLP1 (MACPF-APCβ).

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