Science Advances

Supplementary Materials

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  • fig. S1. Changes in expression levels of BIG1, the related proteins, and myelin marker protein MPZ during sciatic nerve development and the effect of BIG1 or Arf1 knockout on myelination-related transcription factor Krox20 expression.
  • fig. S2. Effects of knockout of BIG1 or Arf1 on Krox20 or MPZ expression during development.
  • fig. S3. Effects of knockout of BIG1 on the amounts of Arf1 in transporting protein complexes.
  • fig. S4. Comparison of thickness between the myelin sheath and the neighboring myelin sheath in Dhh-Cre–mediated BIG1 or Arf1 knockout mice and controls.
  • fig. S5 MPZ-Cre–mediated BIG1 knockout mice exhibit decreased myelin thickness.
  • fig. S6. Staining for the proliferating cell marker (Ki67) in Dhh-Cre–mediated BIG1 knockout and control mouse nerve cross sections and Ki67 expression during development.
  • fig. S7. Staining for the apoptotic cell marker (cleaved caspase-3) in Dhh-Cre–mediated BIG1 knockout and control mouse nerve cross sections and caspase-3 expression during development.
  • fig. S8. MPZ-Cre–mediated Arf1 knockout mice exhibit decreased myelin thickness.
  • fig. S9. Staining for the proliferating cell marker (Ki67) in Dhh-Cre–mediated Arf1 knockout and control mouse nerve cross sections and Ki67 expression during development.
  • fig. S10. Staining for the apoptotic cell marker (cleaved caspase-3) in Dhh-Cre–mediated Arf1 knockout and control mouse nerve cross sections and caspase-3 expression during development.

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