Science Advances

Supplementary Materials

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  • fig. S1. Schematic for the synthesis of the lipid-DOX conjugate.
  • fig. S2. Mass spectroscopy confirmed the conjugation of DOX to PTD.
  • fig. S3. sHDL-DOX was lyophilized and stored for 2 months before reconstitution by adding water to the lyophilized powder.
  • fig. S4. Cellular uptake of DOX or sHDL-DOX by CT26 cells in vitro.
  • fig. S5. Confocal images of CT26 cells and their CRT staining after sHDL-DOX treatment.
  • fig. S6. Biodistribution of Lipo-DiR, PEG-Lipo-DiR, and sHDL-DiR in CT26 tumors in vivo.
  • fig. S7. Intratumoral uptake of DOX or sHDL-DOX in CT26 tumors in vivo.
  • fig. S8. Analysis of DCs in TDLNs after treatment of CT26 tumor-bearing mice with DOX or sHDL-DOX.
  • fig. S9. Antitumor immune responses in the tumor microenvironment.
  • fig. S10. Efficacy of sHDL-DOX + αPD-1 therapy against MCA205 fibrosarcoma.

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