Science Advances

Supplementary Materials

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  • fig. S1. NOL11 predominantly localized in the DFC region within the nucleolus.
  • fig. S2. NOL11 depletion induced down-regulation of rRNA transcription and nucleolar disruption.
  • fig. S3. NOL11 depletion induced nucleolar disruption without undergoing mitosis.
  • fig. S4. Nucleolar disruption is caused by NOL11 depletion alone.
  • fig. S5. Treatment with Act D delayed mitotic entry.
  • fig. S6. The treatment with MK1775 restored the levels of Cdk1-pY15 and the nuclear translocation of cyclin B1.
  • fig. S7. Depletion of NOL11, TIF-IA, or UBF and Act D treatment did not induce DNA damage nor activate G2/M checkpoint.
  • fig. S8. Codepletion of RPL11 suppressed nucleolar disruption and restored the levels of Cdk1-pY15 caused by NOL11 or TIF-IA depletion.
  • table S1. List of siRNAs that increased H3-pS10 levels in asynchronous cultures.

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