Science Advances

Supplementary Materials

This PDF file includes:

  • fig. S1. Schematic diagram of the BBN-induced mouse BCa model.
  • fig. S2. KDM6A functions as a demethylase-dependent and demethylase-independent tumor suppressor of BCa.
  • fig. S3. Schematic diagram and results of the BBN-induced BCa regimen of urothelium-specific Kdm6a cKO mice.
  • fig. S4. KDM6A expression levels in cancer samples are higher among female than male patients.
  • fig. S5. Kaplan-Meier analysis of overall survival of cancer patients stratified by KDM6A expression levels.
  • fig. S6. Candidate XCI escape genes and their mutation rates in human BCa.
  • fig. S7. Expression of the candidate XCI escape genes in BCa tissues from female and male patients.
  • fig. S8. Kaplan-Meier analysis of overall survival of cancer patients stratified by expression levels of the candidate XCI escape genes.
  • fig. S9. A model of molecular basis underlying the sex differences in cancer.
  • table S1. BCa HR of mice with different sex chromosome complement (XX versus XY) or Kdm6a status (wt versus mut).

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