Science Advances

Supplementary Materials

This PDF file includes:

  • fig. S1. Mechanistic in vitro cellular activity of AZD1390.
  • fig. S2. Phenotypic cellular radiosensitization by AZD1390.
  • fig. S3. p53 status and cellular radiosensitization by AZD1390.
  • fig. S4. Pharmacokinetics and pharmacodynamics of AZD1390.
  • fig. S5. PK and PD study of single-dose AZD1390 plus IR in NCI-H2228 ICB model (ICCIN-2012).
  • fig. S6. In vivo activity and toxicology of AZD1390.
  • fig. S7. Patient-derived xenograft model characteristics.
  • table S1. Summary of radiosensitization of glioblastoma cells by irradiation using the colony formation assay.

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