Science Advances

Supplementary Materials

This PDF file includes:

  • Fig. S1. Antiviral kinetics for HIV and HCV vary independently by person.
  • Fig. S2. Standard virologic models highlight different possible actions of ISGs on HIV replication.
  • Fig. S3. IFN-α2b administration results in changes in the proportion of activated CD4+ and CD8+ T cells.
  • Fig. S4. Approach to quantifying and identifying ISGs in RNAs from longitudinally sampled cells.
  • Fig. S5. IFN-α2b induces multiple MX2 isoforms in vivo.
  • Fig. S6. IFN-α2b induces multiple isoforms of CMPK2 and BCL-G.
  • Fig. S7. Baseline gene expression is not associated with plasma HIV RNA levels.
  • Fig. S8. Mean ISG induction and plasma HIV RNA decline.
  • Fig. S9. Interferon-mediated inhibition of HIV in vitro in multiple cell lines.
  • Fig. S10. CMPK2 and MX2 are induced by IFN in THP-1 cells.
  • Fig. S11. Knockdown of CMPK2.
  • Fig. S12. IFN restriction of HIV is dependent on CMPK2 in THP-1 cells.
  • Fig. S13. Expression of myc-tagged BCL-G and MX2 in vitro.
  • Table S1. Participant characteristics.
  • Table S2. RNA-seq metadata.
  • Table S3. qPCR primer sequences and amplicon location by exon.

Download PDF

Files in this Data Supplement: