Science Advances

Supplementary Materials

This PDF file includes:

  • Fig. S1. High-magnification images of 4T1 metastases in lung sections stained for Thy1 and cytokeratin.
  • Fig. S2. Clinical characteristics of study cohorts.
  • Fig. S3. Lymphatic density and its correlation with prognosis.
  • Fig. S4. Correlation of LV density and immune cell infiltration in lung metastases of melanoma patients.
  • Fig. S5. Quantification of the number and size distribution of lung metastatic nodules in the B16F10 model.
  • Fig. S6. Quantification of VEGF-C levels and analysis of LVs in different organs.
  • Fig. S7. Characterization of CCSP-rtTA × tet-O–VEGF-C mice on BALB/c background.
  • Fig. S8. Comparison of 4T1 primary tumor growth and lung metastasis without VEGF-C induction.
  • Fig. S9. Quantification of nodule numbers and size distribution of the lung metastases on day PR21 in the 4T1 model.
  • Fig. S10. 4T1 metastases in distant organs.

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