Science Advances

Supplementary Materials

This PDF file includes:

  • Fig. S1. Principle of FD-based AFM to probe HV binding to living animal cells.
  • Fig. S2. Characterization of MuHV-4 viral particles and validation of tip and surface functionalization.
  • Fig. S3. Attachment and infection of GAG+ and GAG CHO cells.
  • Fig. S4. Exploring a wide range of LRs with FD-based AFM.
  • Fig. S5. Control experiments showing the specificity of MuHV-4 virus binding toward immobilized heparin.
  • Fig. S6. Binding force distribution and multipeak Gaussian fit of different LR sets.
  • Fig. S7. Multipeak Gaussian fit of average rupture forces of gp150 MuHV-4 binding extracted for discrete LRs.
  • Fig. S8. Principle of combined optical and FD-based AFM imaging of animal cells to extract topography images and quantitative multiparametric maps.
  • Fig. S9. Consecutive mapping of WT virus binding to CHO cells shows similar results.
  • Fig. S10. Investigation of virus binding to cells using flow cytometry.

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