Science Advances

Supplementary Materials

This PDF file includes:

  • Fig. S1. Validation of a lentiviral shMC3R vector and viral injections.
  • Fig. S2. α-MSH fails to modulate the frequency or amplitude of TTX-resistant mEPSCs in MC4R PVN neurons.
  • Fig. S3. Neither endocannabinoids nor nitric oxide mediates the α-MSH–induced increase in mIPSC frequency.
  • Fig. S4. Reduction of AgRP cell numbers following DT treatment of AgRP-DTR mice.
  • Fig. S5. Body weight and fat mass changes in response to ovariectomy.
  • Fig. S6. Bidirectional regulation of feeding by MC3R neurons.

Download PDF

Files in this Data Supplement: