Science Advances

Supplementary Materials

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  • Fig. S1. PTPMT1 depletion from neural precursor cells compromises cerebral development.
  • Fig. S2. Active proliferation of GCPs and increased apoptosis in postnatal PTPMT1 knockout cerebella.
  • Fig. S3. Correctly localized BG with radial fibers are missing in PTPMT1 knockout cerebella.
  • Fig. S4. Decreased cell proliferation and increased apoptosis in PTPMT1 knockout cerebra.
  • Fig. S5. Loss of PTPMT1 causes cell cycle arrest in cerebral NSPCs, leading to defective self-renewal and senescence.
  • Fig. S6. Deletion of p53 does not rescue PTPMT1 knockout mice or NSPC self-renewal.
  • Fig. S7. Loss of PTPMT1 causes bioenergetic stress in cerebral NSPCs.
  • Fig. S8. The entire cerebral cortex cell population is less affected by PTPMT1 ablation.

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