Science Advances

Supplementary Materials

This PDF file includes:

  • Supplementary Materials and Methods
  • Fig. S1. Characterization of MoS2 nanosheets.
  • Fig. S2. Identification of DOX fingerprint mass peak.
  • Fig. S3. Average ion intensity ratios of the DOX/PEG-MoS2 with different loading ratios.
  • Fig. S4. Representative LDI MS spectra in mice tissues.
  • Fig. S5. LDI MSI images of tissues in normal mice.
  • Fig. S6. LDI MSI images of tissues injected with bare and LA-PEG–modified MoS2 nanosheets (PEG-MoS2) in normal mice.
  • Fig. S7. Suborgan distribution of MoS2 nanosheets in normal mouse spleen.
  • Fig. S8. H&E-stained images of tissues from the tumor model mice.
  • Fig. S9. LDI MSI images of tissues in subcutaneous implanted tumor models.
  • Fig. S10. Distribution of bare MoS2 nanosheets in the liver of orthotopic H22 tumor model mice after 48-hour intravenous injection.
  • Fig. S11. LDI MSI images of MoS2 nanosheets and their payload DOX in tissues of normal mice.
  • Fig. S12. Representative LDI mass spectra of DOX/PEG-MoS2–injected mouse tissue slices.
  • Fig. S13. Drug release from DOX/PEG-MoS2 nanosheets at different pH values as a function of time.
  • Fig. S14. LDI MSI images of CNTs (carbon nanotubes) and their payload DOX in tissues.
  • Fig. S15. LDI MSI images of black phosphorus nanosheets and their payload DOX in tissues.
  • Fig. S16. LDI MSI images of gold nanoparticles and their payload DOX in tissues.
  • Fig. S17. Standard calibration curves for bare MoS2 nanosheets in tissues.
  • References (3540)

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