Science Advances

Supplementary Materials

This PDF file includes:

  • Fig. S1. Three-dimensional structural comparison of the binding between ponatinib and Abl, FGFR4, and MEKK3.
  • Fig. S2. Two-dimensional mapping of ponatinib interaction with Abl, FGFR4, and MEKK3.
  • Fig. S3. CCM1, p38, and MEKK3 expression in cultured HUVECs.
  • Fig. S4. MEKK3 is the dominant regulator of KLF signaling.
  • Fig. S5. Confocal images of Tg(cmlc2:EGFP) embryos injected with control, ccm2, or ccm2 + mekk2 morpholinos.
  • Fig. S6. Effects of ponatinib and other kinase inhibitors on KLF2 expression.
  • Fig. S7. qPCR quantification of CCM gene expression in brain endothelial cells isolated from 4-HT–induced p6 pups.
  • Fig. S8. Hematoxylin and eosin staining of CCM lesions at P13.
  • Fig. S9. Hematoxylin and eosin staining of CCM lesions at P30.

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