Science Advances

Supplementary Materials

The PDF file includes:

  • Fig. S1. Phosphorylation of RAB7A by TBK1.
  • Fig. S2. Analysis of RAB7AS72A and RAB7AS72E mutants.
  • Fig. S3. Analysis of PARKIN-dependent mitophagy in RAB7A and FLCN mutant cells.

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Other Supplementary Material for this manuscript includes the following:

  • Data file S1 (Microsoft Excel format). Phosphoproteomic data for TBK1WT and TBK1−/− cells in response to mitochondrial depolarization (corresponds to experiment in Fig. 1).
  • Data File S2 (Microsoft Excel format). Total proteome quantification for cell extracts used in the phosphoproteomic data in Fig. 1 and data file S1.
  • Data File S3 (Microsoft Excel format). Phosphoproteome data for PARKINWT and PARKINS65A cells, as well as PINK1−/− cells in the presence and absence of depolarization (corresponds to experiment in Fig. 2).
  • Data File S4 (Microsoft Excel format). Protein interaction proteomic data for FLAG-HA-RAB7AWT, S72A, and S72E with and without mitochondrial depolarization.
  • Data File S5 (Microsoft Excel format). Proteomic data for lysosomes purified from RAB7AWT or RAB7AS72A cells in response to depolarization (corresponds to experiment in Fig. 6).

Files in this Data Supplement: