Science Advances

Supplementary Materials

The PDF file includes:

  • Fig. S1. IDH3α is confined to the nuclear periphery and highly expressed in the tumor-associated vasculature.
  • Fig. S2. IDH3α regulates cellular invasiveness.
  • Fig. S3. Subcellular redistribution of IDH3α and colocalization with cSHMT.
  • Fig. S4. Effect of IDH3α ablation on glycolysis, TCA, and folate one-carbon metabolism.
  • Fig. S5. IDH3α KO does not affect global histone methylation status but affects DNA methylation.
  • Fig. S6. IDH3α loss of function through impact on DNA methylation regulates gene expression.
  • Fig. S7. IDH3α expression affects MTX treatment response.
  • Legend for table S1

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Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). Alterations in IDH3α expression lead to widespread metabolomic changes.

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