Science Advances

Supplementary Materials

This PDF file includes:

  • Fig. S1. slo-1 mutant worms exhibit slower locomotor activity decline throughout life span.
  • Fig. S2. slo-1 gain-of-function mutation greatly shortens life span.
  • Fig. S3. DAF-16 target gene expression and DAF-16 nuclear translocation in slo-1 mutant worms.
  • Fig. S4. slo-1 and IIS act in parallel to regulate life span.
  • Fig. S5. Expression of daf-16 cDNA in the muscle fails to rescue the daf-16 mutant phenotype.
  • Fig. S6. The effects of different concentrations of paxilline on life span and motor aging.
  • Fig. S7. Loss of slo-1 does not extend the life span of mutants defective in neurotransmission.
  • Table S1. Summary of life-span data.

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