Science Advances

Supplementary Materials

This PDF file includes:

  • Fig. S1. AR3 epitopes.
  • Fig. S2. Binding of AR3A–D and AR1A IgGs to E2.
  • Fig. S3. Binding and neutralization of AR3 mAbs to HCV isolates from genotypes 1 to 6.
  • Fig. S4. Crystal structures of HK6a E2c3 with AR3 Fabs.
  • Fig. S5. Features that enable broad neutralization by AR3.
  • Fig. S6. The inferred GL genes of the AR3 mAbs.
  • Fig. S7. Identity/divergence analysis of the phage display library from an HCV-infected donor.
  • Fig. S8. B cell repertoire of healthy and HCV-infected donors.
  • Fig. S9. Primers that were used for amplification of the HC regions of the Fab phage libraries in the different panning steps.
  • Fig. S10. Summary of the statistic analysis of the NGS of HCV chronically infected and healthy donors.
  • Table S1. Amino acid sequence variation of the E2 protein of HCV genotypes 1 to 7.
  • Table S2. Data collection and refinement statistics for HK6a E2c3 AR3 Fab complex structures.
  • Table S3. Hydrogen bond and hydrophobic interactions between E2 and the HC of AR3 Fabs.
  • Table S4. NGS of HCV-immune Ab repertoire of an HCV-infected patient.
  • Table S5. NGS of HCV-immune Ab repertoires.
  • References (6568)

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