Science Advances

Supplementary Materials

This PDF file includes:

  • Fig. S1. Selective infection of memory CD4 T cells by CCR5-utilizing HIV-1.
  • Fig. S2. R10015 does not alter the CXCR4 receptor surface density.
  • Fig. S3. Surface expression of α4β7 on different subsets of human blood resting CD4 T cells, as measured by surface staining and flow cytometry.
  • Fig. S4. R10015 does not alter the α4β7 receptor surface density.
  • Fig. S5. Act-1 is not a chemoattractant.
  • Fig. S6. Act-1 selectively promotes the migration of the α4β7high CD4 T cells.
  • Fig. S7. Act-1 does not selectively promote the migration of the CCR7+ CD4 T cells.
  • Fig. S8. Act-1 stimulation does not activate resting CD4 T cells.
  • Fig. S9. Act-1 is not effective in rescuing T cell motility with high levels of cofilin hyperactivation.
  • Fig. S10. Accumulation of the α4β7high CD4 T cells in the peripheral blood of HIV-infected patients.
  • Table S1. Characteristics of clinical study participants.
  • Table S2. Patient enrollment and grouping.

Download PDF

Files in this Data Supplement: