Science Advances

The PDF file includes:

• Fig. S1. Cell death cellular markers in rat retinal explants exposed to iron.
• Fig. S2. TF expression in mouse retinal explants protects from low-serum culturing conditions.
• Fig. S3. TF expression in mouse retina explants reduced oxidative stress markers induced by iron.
• Fig. S4. TF treatment preserves iron-exposed rat retinal explants from oxidative stress and inflammation.
• Fig. S5. Animal models of RD.
• Fig. S6. Iron accumulates in the rodent retina following RD.
• Fig. S7. The expression of the TF protein partner, IGFBP3, in mice following RD.
• Fig. S8. Proposed role of IGFBP3 in the protective effect of TF.
• Table S1. Top 20 up- and down-regulated genes in TG compared with WT mice following RD.
• Table S2. Pathways and genes regulated by TF and implicated in PR rescues.
• Legend for data file S1
• References (35–44)

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Other Supplementary Material for this manuscript includes the following:

• Data file S1 (Microsoft Excel format). Complete transcriptomic analysis.