Science Advances

Supplementary Materials

This PDF file includes:

  • Fig. S1. NDR2 specifically enhances RNA virus–induced IFN-β, IL-6, and TNF-α production in macrophages in a kinase-independent manner.
  • Fig. S2. NDR2 protects mice from RNA virus infections.
  • Fig. S3. NDR2 enhances RIG-I pathway activation in a kinase-independent manner.
  • Fig. S4. Schematic structure of NDR2 and TRIM25 and their derivatives.
  • Fig. S5. NDR2 promotes TRIM25-mediated K63-linked polyubiquitination of RIG-I.
  • Fig. S6. Virus infections inhibit NDR2 expression via STAT1-dependent mechanism.
  • Table S1. List of antibody information.
  • Table S2. List of primers for qPCR.
  • Table S3. List of gRNAs for CRISPR-CAS9.

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