Science Advances

Supplementary Materials

The PDF file includes:

  • Supplementary Materials and Methods
  • Fig. S1. ERα-DOT1L association.
  • Fig. S2. ERα-DOT1L functional interaction.
  • Fig. S3. DOT1L inhibition reduces the proliferation of ERα-positive BC cells.
  • Fig. S4. DOT1L inhibition in ERα-negative BC cell proliferation.
  • Fig. S5. DOT1L pharmacological inhibition in ERα-positive and ERα-negative 3D BC cell models.
  • Fig. S6. EPZ affects ESR1 activity and ERα-DOT1L binding affinity.
  • Fig. S7. Functional effect of alternative DOT1L inhibitors.
  • Fig. S8. Effects of DOT1L silencing by short hairpin RNAs on proliferation and estrogen-mediated gene expression in MCF-7 cells.
  • Fig. S9. Transcriptome analyses of MCF-7 and LCC2 cells following TAM treatment or DOT1L pharmacological inhibition.
  • Fig. S10. DOT1L pharmacological inhibition in SERM- and SERD-resistant BC cell models.
  • References (5054)

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Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). ChIP-MS data.
  • Table S2 (Microsoft Excel format). ChIP-seq data.
  • Table S3 (Microsoft Excel format). Nascent-seq data in MCF-7 cells.
  • Table S4 (Microsoft Excel format). RNA-seq data in MCF-7 cells.
  • Table S5 (Microsoft Excel format). Microarray data in MCF-7 and ZR-75.1 cells.
  • Table S6 (Microsoft Excel format). eRNA data.
  • Table S7 (Microsoft Excel format). RNA-seq data in LCC2 cells.

Files in this Data Supplement: