Science Advances

Supplementary Materials

The PDF file includes:

  • Fig. S1. Expressions of Tie2 and Angpt1 in the RPE-choroid complex.
  • Fig. S2. Generation of en face OCT angiograms for measurement of retinal and choroidal blood flow.
  • Fig. S3. Elevated IOP is not responsible for reduced choroidal blood flow.
  • Fig. S4. Global Angpt1 deletion in adult mice causes damage and loss of choriocapillaris.
  • Fig. S5. Loss of cone but not of rod photoreceptor in the eyes of global Angpt1-depleted mice.
  • Fig. S6. ABTAA promotes regeneration of choriocapillaris surrounding the site of laser photocoagulation in the prevention phase.
  • Fig. S7. ABTAA forms the Angpt2-Tie2-ABTAA complex in the mouse CNV model.
  • Fig. S8. Analyses of the effects of ABTAA treatment in adult Tie2-depleted mice.
  • Fig. S9. RNA-seq analysis of CNV lesions and surrounding tissues treated with VEGF-Trap and ABTAA.
  • Fig. S10. ABTAA binds to ANGPT2 and activates TIE2 and its downstream effectors.

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Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). List of disease and biological function signatures identified by IPA in the CNV lesions and the surrounding RPE-choroid complex treated with VEGF-Trap or ABTAA, related to fig. S9 (E and F).

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