Science Advances

Supplementary Materials

This PDF file includes:

  • Supplementary Materials and Methods
  • Scheme S1. Synthesis of pacRNA.
  • Fig. S1. Synthetic scheme and characterization of dibenzocyclooctyne-modified RNA.
  • Fig. S2. Additional characterization of brush polymers and pacRNAs.
  • Fig. S3. Cellular uptake of PO siRNA, PS RNA, and pacRNA in SKOV3 cells.
  • Fig. S4. Cellular uptake of PO siRNA, PS RNA (ss and ds), and pacRNA in SKBR3 cells.
  • Fig. S5. Representative confocal images of SKBR3 cells treated with Cy3-labeled ss PS RNA or ds PS RNA for 4 h.
  • Fig. S6. Bcl-2 down-regulation and cell apoptosis induced by pacRNA.
  • Fig. S7. Fluorescence images of SKOV3 tumor cryosections following intravenous injections of siRNA, pacRNAs, and brush polymers.
  • Fig. S8. Microscopic images of H&E-stained sections of various organs from mice after a 32-day treatment period with pacRNAs and PBS showing no apparent histological anomalies.
  • Table S1. Oligonucleotide sequences.
  • Table S2. Plasma pharmacokinetic parameters in C57BL/6 mice.
  • References (4551)

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