Science Advances

Supplementary Materials

This PDF file includes:

  • Fig. S1. Salt formation of rutin benefits absorption and crosses the BBB in mice.
  • Fig. S2. The effect of rutin or NaR on Aβ burden in 5XFAD mice.
  • Fig. S3. NaR ameliorates learning and memory deficits, rescues synaptic impairment, and reduces Aβ burden in 5XFAD mice.
  • Fig. S4. NaR treatment reduces neuroinflammation in AD mice.
  • Fig. S5. NaR reduces proliferation but increases migration of microglia.
  • Fig. S6. NaR increases the expression of phagocytic receptors and enhances microglial Aβ phagocytosis.
  • Fig. S7. Subcellular localization of biotin-rutin.
  • Fig. S8. NaR rescues energetic metabolism deficit in Trem2 KO microglia.
  • Fig. S9. NaR fails to alter mitochondrial OXPHOS in primary cultured neurons and astrocytes.
  • Fig. S10. Proposed working model of NaR.
  • Table S1. List of qPCR primers.

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