Science Advances

Supplementary Materials

This PDF file includes:

  • Fig. S1. Domain organization in the type I phosphodiesterase superfamily.
  • Fig. S2. Domain organization and primary sequence comparison between PDE6α and PDE6β subunits.
  • Fig. S3. Biochemical characterization and cryo-EM of the PD6αβ2γ complex.
  • Fig. S4. Structural features of regulatory GAF domains of the PDE6αβ2γ complex.
  • Fig. S5. Comparison between the H-loop orientations of PDE6 and PDE5.
  • Fig. S6. Cryo-EM reconstruction and data fitting of the PDE6αβ2γ complex.
  • Table S1. Cryo-EM data collection, refinement, and validation statistics for the PDE6αβ2γ complex.

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