Science Advances

Supplementary Materials

The PDF file includes:

  • Fig. S1. Optogenetic targeting projections from LH neurons to neurons in the DBB.
  • Fig. S2. Electrophysiological recordings on DDB neurons that receive monosynaptic inputs from LH neurons.
  • Fig. S3. Tracing DDB neurons that receive direct inputs from LH.
  • Fig. S4. Tracing LH neurons that send direct projections to DBB neurons.
  • Fig. S5. LHGABA neurons send direct projections to the DBB.
  • Fig. S6. Optogenetic stimulation of LHGABA to DBB projections increased food-dependent exploratory behavior.
  • Fig. S7. Competition between anxiogenic conditions and feeding behavior.
  • Fig. S8. Verification of synthetic excitatory receptor (hm3Dq) expression in DBB neurons.
  • Legends for movies S1 to S3

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Other Supplementary Material for this manuscript includes the following:

  • Movie S1 (.mp4 format). Activation of LHVgatDBB fibers (laser ON) induces immediate increase in sniffing, licking, and exploratory behavior, followed by consumption of chow.
  • Movie S2 (.mp4 format). Fiber photometry data of novel object interaction.
  • Movie S3 (.mp4 format). Fiber photometry data of food consumption after 24-hour fasting.

Files in this Data Supplement: