Science Advances

Supplementary Materials

The PDF file includes:

  • Fig. S1. Chromatin capture from pluripotent ESCs by Dm-ChP.
  • Fig. S2. Culture conditions for Dm-ChP are compatible with normal physiology.
  • Fig. S3. Biological and pathologically relevant chromatin-associated proteins in ESCs.
  • Fig. S4. Expression of key developmental genes during early mammalian development.
  • Fig. S5. AHCY is recruited to the TSS of transcriptionally active genes.
  • Fig. S6. Expression of pluripotency genes upon Ahcy knockdown.
  • Fig. S7. Proteomic analysis of ribosomal protein encoded by AHCY targets.
  • Fig. S8. Inhibition of AHCY reduces rate of protein synthesis.
  • Fig. S9. Gating strategy for cell cycle and HPG incorporation analysis by FACS.

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Other Supplementary Material for this manuscript includes the following:

  • Table S1 (.pdf format). Principal methods developed to identify protein components of the chromatin.
  • Table S2 (Microsoft Excel format). Proteomic data.
  • Table S3 (Microsoft Excel format). ChIP-seq data.
  • Table S4 (Microsoft Excel format). RNA-seq data.

Files in this Data Supplement: